Isolated hepatic melphalan perfusion of colorectal liver metastases: outcome and prognostic factors in 154 patients
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چکیده
منابع مشابه
Isolated hepatic melphalan perfusion of colorectal liver metastases: outcome and prognostic factors in 154 patients.
BACKGROUND The aim of this study was to identify prognostic factors for local and systemic failure after isolated hepatic perfusion (IHP) with 200 mg melphalan in patients with colorectal liver metastases. PATIENTS AND METHODS Hundred and fifty-four patients were selected for IHP and underwent laparotomy. Patients were monitored for response, toxicity and survival. Univariate and multivariate...
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PURPOSE Liver metastases are the sole or life-limiting component of disease in the majority of patients with ocular melanoma who recur. Because median survival after diagnosis of liver metastases is short and no satisfactory treatment options exist, we have conducted clinical trials evaluating isolated hepatic perfusion (IHP) for patients afflicted with this condition. EXPERIMENTAL DESIGN Twe...
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BACKGROUND Isolated hepatic perfusion (IHP) involves complete vascular isolation of the liver to allow treatment with doses that would be toxic if delivered systemically. A phase II study of IHP in patients with colorectal metastases confined to the liver was performed. METHODS Seventy-three patients with irresectable colorectal metastases underwent IHP with high-dose melphalan (200 mg) for 1...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2008
ISSN: 0923-7534
DOI: 10.1093/annonc/mdn032